Contact Details

Curriculum Vitae

Patrick de Zeeuw is a post-doctoral researcher at the NICHE Neuroimaging lab of the Department of Child and Adolescent Psychiatry at the University Medical Centre Utrecht. He completed an M.Sc. in Clinical Neuropsychology (specialisation: Developmental Neuropsychology) at the VU University Amsterdam in 2005. In October 2011, he received his Ph.D. in from Utrecht University with a dissertation entitled Neurobiological Heterogeneity in ADHD. His research interests are the neurobiological and neuropsychological background of developmental disorders, disruptive disorders in particular.

Current Research Projects

Profiling ADHD: structural MRI and DTI in children with ADHD
The aim of the project is to integrate sturctural neuroimaging, cognitive performance data and genotypic information in ADHD. To achieve this, a large group of children with ADHD and controls will be scanned using both structural Magnetic Resonance Imaging (sMRI) and Diffusion Tensor Imaging (DTI). Additionally, tests tapping cognitive functions which are known to be deficient in ADHD will be administered. These include tests of cognitive control, sensitivity to effects of stimulus timing and sensitivity to reward. DNA will be obtained from participants and their parents for genotyping. Candidate genes that will be investigated are genes which have been associated with ADHD and have been subsequently replicated, thus covering multiple (neurotransmitter) pathways. Of main interest in this large cohort study is describing brain development in ADHD, as well as the influence of genetic vulnerability and presence of cognitive deficits on brain development in ADHD.

List of Publications

Papers

• De Zeeuw, P., Mandl, R.C.W., Hulshoff-Pol, H.E., Van Engeland, H., & Durston, S. (2011) Decreased frontostriatal microstructural organization in ADHD. Human Brain Mapping. DOI: 10.1002/hbm.21335. [link to paper]
• Durston, S., Van Belle, J., & De Zeeuw, P. (2011). Differentiating frontostriatal and fronto-cerebellar circuits in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry, 69(12), 1178-1184.
• De Zeeuw, P. (2011). Imaging genetics bij ADHD: effecten van genetisch risico op hersenanatomie en hersenfunctie in beeld gebracht. [Imaging genetics in ADHD: visualizing the effect of genetic risk on brain anatomy and function; in Dutch]. Tijdschrift voor Neuropsychologie, 6(1), 29-37. [link to paper]
• Durston, S., De Zeeuw, P., & Staal, W.G. (2009). Imaging genetics in ADHD: A focus on cognitive control. Neuroscience and Biobehavioral Reviews, 33(5), 674-689.
• Durston, S., Nederveen, H., Van Dijk, S., Van Belle, J., De Zeeuw, P., Langen, M., & Van Dijk, A. (2009). MR simulation is effective for reducing anxiety related to MR scanning in children. Journal of The American Academy of Child and Adolescent Psychiatry, 48(2), 206-207.
• De Zeeuw, P., Aarnoudse-Moens, C., Bijlhout, J., König, C., Post Uiterweer, A., Papanikolau, A., Hoogenraad, C., Iemandt, L., De Been, D., Sergeant, J.A., & Oosterlaan, J. (2008). Inhibitory performance, response speed, intra-individual variability, and response accuracy in ADHD. Journal of The American Academy of Child and Adolescent Psychiatry, 47(7), 808-816. [link to paper]

Posters/Abstracts

• De Zeeuw, P., Mandl, R.C.W., & Durston, S. (2010). Fronto-striatal structural connectivity in ADHD assessed using combined Diffusion Tensor and Magnetisation Transfer Imaging. Oral Presentation at the Junior Eunethydis Meeting 2010, Amsterdam, The Netherlands.
• De Zeeuw, P.,  Schnack, H.G., Brouwer, R.M., Van Belle, J., Weusten, J.M., Van Dijk, S., & Durston, S. (2010). General cognitive functioning as a moderator of differences in brain anatomy between children with ADHD and controls. Poster presented at the Eunethydis Meeting 2010, Amsterdam, The Netherlands.
• De Zeeuw, P., & Durston, S. (2010). Measuring reward sensitivity in ADHD. Poster presented at the Eunethydis Meeting 2010, Amsterdam, The Netherlands.
• De Zeeuw, P., Van Belle, J., Van Dijk, S.A., Schnack, H., Van Haren, N.E.M., Van Engeland, H., & Durston, S. (2009). Anatomical MRI of brain development in a large cohort of children with ADHD and controls. Poster presented at the 15th Annual Meeting of the Organization for Human Brain Mapping, June 2009, San Francisco, USA.
• De Zeeuw, P., Van Belle, J., Van Dijk, S.A., Schnack, H., Van Haren, N.E.M., Van Engeland, H., & Durston, S. (2008). Anatomical Magnetic Resonance Imaging in ADHD. Poster presented at the Eunethydis Meeting 2008, October 2008, Mannheim, Germany.